| In order to investigate the interaction of microscopic parameters of cohesioness granular, rolling resistance contact model was employed in traixial compression test with different microscopic parameters via the Discrete Element Method. In this simulation, five microscopic parameters was adopted, namely, contact stiffness ratio (0.3-0.9), coefficient of rolling stiffness (0.1-3), normal stiffness (1?07-7?07), internal friction angle (10-40) and coefficient of plastic moment (0.1-3), respectively. Meanwhile, parametric studies on five macroscopic parameters, namely, peak stress , residual strength , Young’s modulus , Poisson’s ratio and friction angle . Firstly, comprehensive and factorial experiment design have carried out to conduct a qualitative analysis on the interaction between microscopic parameters and macroscopic parameters, and then multiple nonlinear regression was adopted to analyze the interaction quantificationally. A theoretical formula between macroscopic and microscopic parameters was proposed also, taking the interaction into consideration. The result shows that: (1) Particle internal friction angle and rolling resistance parameters have a significant influence on macroscopic strength parameters, and it’s deformation parameters are mainly determined by particle contact stiffness and contact stiffness ratio. (2)There are interactions between microscopic parameters and macroscopic parameters at different degrees, which have certain effects on the sample’s macroscopic properties; (3) As to peak stress, residual stress and internal friction angle, the interactions between two rolling resistance parameters, as well as rolling resistance parameters and particle friction angle are relatively strong. Furthermore, there is a significant interaction between normal contact stiffness and other parameters, which has an influence on Young’s modulus and Poisson ratio, The study has a directive meaning to quickly and reasonably determine the microscopic parameters of DEM model.